Vitamin E is a major antioxidant and the primary defense against lipid peroxidation. It is particularly important in protecting the body’s cells from free radical/oxidative damage. These protective benefits are achievable with supplemental intakes higher than what is normally consumed in the average diet. From the FDA’s website: "Some scientific evidence suggests that consumption of antioxidant vitamins may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive." Supplement Facts Serving Size: 1 Softgel Amount Per Serving % Daily Value Vitamin E (as d-alpha Tocopheryl Acetate) 1000 IU 3330% 100% Nnatural d-alpha Tocopheryl Suggested Use: As a dietary supplement, take one Vitamin E softgel daily, preferably with meals. Free of: yeast, wheat, corn, milk, synthetics, preservatives. Other Ingredients: vegetable oil concentrate, gelatin, glycerin and water. What type of vegetable oil is used in your Vitamin E softgels? The vegetable oil used in our Vitamin E products is soybean oil. For those persons allergic to soy or soy products, try NOW® Dry E-400 capsules or powder. This product is free of any soy ingredients. What’s the difference between Alpha and Gamma and Tocopherol? In order to answer the question correctly we need to review what Vitamin E is. Vitamin E is a family of essential fat-soluble nutrients that act as powerful antioxidants. In nature there are 8 substances that have been found to have vitamin E activity: alpha-, beta-, gamma- and delta-tocopherol; and alpha-, beta-, gamma- and delta tocotrienols. The four different isomers from both the tocopherol and tocotrienol groups all have different biological activities and therapeutic benefits. According to research d-alpha-tocopherol has the highest bioavailablity and is the standard against which all the others must be compared. Human blood and tissue contains much more alpha-tocopherol than gamma-tocopherol even though gamma-tocopherol is the predominant form of vitamin E in our diet. It’s suggested that the liver metabolizes both alpha and gamma forms but uses a special protein called alpha-tocopherol transfer protein to preferentially place more alpha than any other tocopherol into the VLDL and eventually the LDL cholesterol carries it through the bloodstream to the tissues. The liver metabolizes gamma-tocopherol to 2,7,8-trimethyl-2- (beta-carboxyethyl)-6-hydroxychromin (gamma-CEHC) which is absorbed in some tissues, sent back to the intestines via the bile and mostly excreted in the urine. Some research indicates that the active CEHC metabolite may have natriuretic activity and play a role in determining how much fluid and electrolytes may pass through the kidneys thereby influencing many important physiologic activities in the body.
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