Pregnenolone 10 mg, 25 mg and 50 mg Tablets Pregnenolone is the starting point from which all steroid hormones are manufactured in our bodies. Its conversion in the body follows different pathways, depending on individual needs. Several clinical studies have demonstrated that pregnenolone may enhance psychomotor performance and decrease fatigue in healthy subjects. Pregnenolone – The Balancing Hormone Pregnenolone – a hormone produced from cholesterol in our adrenal glands, liver, skin, testicles, ovaries, and brain – was the subject of intense interest in the 1940’s. Some of the earliest studies, performed by well-known researcher Hans Selye, found it to be helpful in reducing stress and fatigue. Additional studies were conducted throughout the decade, with positive results. Pregnenolone supplementation was found to benefit people who were under excessive stress. It also was reported to support joint and tissue function and to contribute to skin elasticity. Pregnenolone is believed to affect stress levels through its influence on the adrenal glands, which produce more steroid hormones when people are under stress. Pregnenolone may also affect brain chemistry in beneficial ways. It has been found to inhibit the GABA receptors in brain cells – which may result in increased mental alertness. It may also stimulate the NMDA (N-methyl-D-aspartate) receptors, which play an important role in regulating synapses, thus influencing learning and memory. Pregnenolone – The Unique Hormone Much of the current interest in pregnenolone is related to its role as "the grandmother of all steroid hormones". Pregnenolone is the starting point from which all steroid hormones are manufactured in our bodies. As a "hormone balancer", it has the capacity to increase the levels of steroid hormones that are deficient in our bodies and to reduce the levels of excess circulating hormones. Some scientists believe pregnenolone is converted into other hormones only as they are needed by our bodies. The conversion of pregnenolone follows different pathways, depending upon cellular requirements. Pregnenolone may be converted into DHEA (dehydroepiandrosterone), which in turn can be changed into androgens (including testosterone), estrogens and other steroids; or, it may be converted into any or all of a chain of hormones including progesterone, corticosterone, and aldosterone. These characteristics make pregnenolone unique. Because cells may only convert pregnenolone into other hormones on an "as needed" basis, pregnenolone may correct imbalances in the levels of some hormones, without affecting others. This is a great advantage over steroid hormones like DHEA, which may create excess estrogen and testosterone. Pregnenolone is also distinctive because of the innumerable bodily activities it can influence. As a steroid hormone precursor, it is believed to be involved in every biochemical action exhibited by any steroid hormone. This means it may impact memory, mental alertness, stress responses, female reproductive cycles, the body’s natural defenses, and joint and tissue function. With such a wide spectrum of involvement, the potential uses of pregnenolone could be boundless. Source Naturals Pregnenolone is available in 10 mg sublinguals and tablets, as well as in 25 mg tablets. All potencies are sold in 60 and 120 tablet bottles. Supplement Facts for 50 mg Serving Size: 1 tablet Amount %DV Vitamin C (as ascorbyl palmitate) 21 mg Pregnenolone 50 mg Other Ingredients: sorbitol, mannitol, colloidal silicon dioxide, stearic acid and magnesium stearate. Warning: Not for use by persons under 40, or pregnant or breastfeeding women. Do not take Pregnenolone if you have severe benign prostatic hypertrophy, or hormone-responsive cancer, including estrogen-dependent breast cancer or prostate cancer. Consult your physician before taking PREG if you have any medical condition including high blood pressure, diabetes, epilepsy, liver disease or a kidney, thyroid, adrenal or immune system disorder, or if you are taking any medication including corticosteroids, asthma medication, calcium channel blockers, benzodiazepines, barbiturates, anti-anxiety drugs, oral contraceptives, progesterone, progestin or are on estrogen replacement therapy. Suggested Use: One Pregnenolone tablet daily, or as directed by your physician. One half tablet may be sufficient for some persons. Do not exceed one tablet per day. Do not take for more than 30 days without the advice of your physician, and have your blood hormone (estrogen, testosterone, DHEA) levels regularly assessed by your physician. Using pregnenolone (PREG) may elevate your DHEA levels, and DHEA can increase estrogen and testosterone levels. Read entire label before using Pregnenolone. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no starch, salt, or artificial color, flavor, or fragrance.
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